Proteomics

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Transgenic Eimeria acervulina LC-MSMS

ABSTRACT: We constructed genetically modified Eimeria acervulina that expressed VP2 protein, a protective antigen from infectious bursal disease virus (IBDV), on the surface or in the microneme of sporozoites. we identified the transgenic E. acervulina expressing VP2 by RT-qPCR,LC-MSMS and Werstern Blot.

ORGANISM(S): Eimeria Acervulina

SUBMITTER: Xun Suo  

PROVIDER: PXD046252 | iProX | Fri Oct 20 00:00:00 BST 2023

REPOSITORIES: iProX

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Microneme-located VP2 in <i>Eimeria acervulina</i> elicits effective protective immunity against infectious bursal disease virus.

Yu Ying Y   Tang Xinming X   Duan Chunhui C   Suo Jingxia J   Crouch Colin C   Zhang Sixin S   Liu Xianyong X   Liu Jie J   Bruton Beth B   Tarpey Ian I   Suo Xun X  

Infection and immunity 20240105 2

Using transgenic <i>Eimeria</i> spp. to deliver exogenous antigens is a viable option for developing multivalent live vaccines. Previous research revealed that the location of antigen expression in recombinant <i>Eimeria</i> dictates the magnitude and type of immune responses. In this study, we constructed genetically modified <i>Eimeria acervulina</i> that expressed VP2 protein, a protective antigen from infectious bursal disease virus (IBDV), on the surface or in the microneme of sporozoites.  ...[more]

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