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Skeletal muscle-secreted DLPC orchestrates systemic energy homeostasis by enhancing adipose browning

ABSTRACT: Skeletal muscle-secreted DLPC orchestrates systemic energy homeostasis by enhancing adipose browning

ORGANISM(S): Mus Musculus

SUBMITTER: Dahai Zhu

PROVIDER: PXD046337 | iProX | Tue Oct 24 00:00:00 BST 2023

REPOSITORIES: iProX

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Skeletal muscle-secreted DLPC orchestrates systemic energy homeostasis by enhancing adipose browning.

Hu Xiaodi X Sun Mingwei M Chen Qian Q Zhao Yixia Y Liang Na N Wang Siyuan S Yin Pengbin P Yang Yuanping Y Lam Sin Man SM Zhang Qianying Q Tudiyusufu Alimujiang A Gu Yingying Y Wan Xin X Chen Meihong M Li Hu H Zhang Xiaofei X Shui Guanghou G Fu Suneng S Zhang Licheng L Tang Peifu P Wong Catherine C L CCL Zhang Yong Y Zhu Dahai D

Nature communications 20231130 1

MyoD is a skeletal muscle-specifically expressed transcription factor and plays a critical role in regulating myogenesis during muscle development and regeneration. However, whether myofibers-expressed MyoD exerts its metabolic function in regulating whole body energy homeostasis in vivo remains largely unknown. Here, we report that genetic deletion of Myod in male mice enhances the oxidative metabolism of muscle and, intriguingly, renders the male mice resistant to high fat diet-induced obesity ...[more]

PMID: 38036537

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