Dataset Information
Skeletal muscle-secreted DLPC orchestrates systemic energy homeostasis by enhancing adipose browning
Ontology highlight
ABSTRACT:
ORGANISM(S): Mus Musculus
SUBMITTER: 
Dahai Zhu
PROVIDER: PXD046337 | iProX | Tue Oct 24 00:00:00 GMT+01:00 2023
REPOSITORIES: iProX
Publications
Skeletal muscle-secreted DLPC orchestrates systemic energy homeostasis by enhancing adipose browning.
Nature communications 20231130 1
MyoD is a skeletal muscle-specifically expressed transcription factor and plays a critical role in regulating myogenesis during muscle development and regeneration. However, whether myofibers-expressed MyoD exerts its metabolic function in regulating whole body energy homeostasis in vivo remains largely unknown. Here, we report that genetic deletion of Myod in male mice enhances the oxidative metabolism of muscle and, intriguingly, renders the male mice resistant to high fat diet-induced obesity ...[more]
