Targeting NADPH oxidase and integrin α5β1 to inhibit neutrophil extracellular traps-mediated metastasis in colorectal cancer
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ABSTRACT:
ORGANISM(S): Homo Sapiens
SUBMITTER: 
Jianguo Ji
PROVIDER: PXD046490 | iProX | Fri Oct 27 00:00:00 BST 2023
REPOSITORIES: iProX
Publications
Targeting NADPH Oxidase and Integrin α5β1 to Inhibit Neutrophil Extracellular Traps-Mediated Metastasis in Colorectal Cancer.
Zhu Wenyuan W Yang Siqi S Meng Delan D Wang Qingsong Q Ji Jianguo J
International journal of molecular sciences 20231106 21
Metastasis leads to a high mortality rate in colorectal cancer (CRC). Increased neutrophil extracellular traps (NETs) formation is one of the main causes of metastasis. However, the mechanism of NETs-mediated metastasis remains unclear and effective treatments are lacking. In this study, we found neutrophils from CRC patients have enhanced NETs formation capacity and increased NETs positively correlate with CRC progression. By quantitative proteomic analysis of clinical samples and cell lines, w ...[more]
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