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DIA-Based Quantitative Proteome Profiling of Aqueous Humor of Diabetic Retinopathy

ABSTRACT: Diabetic retinopathy (DR) is a leading cause of irreversible vision impairment and blindness. To explore the dynamics of aqueous humor (AH) protein profiles during four stages from non-diabetic individuals to proliferative diabetic retinopathy patients, especially to improve our understanding of pathophysiological mechanisms of proliferative diabetic retinopathy (PDR).

ORGANISM(S): Homo Sapiens

SUBMITTER: Qianli Meng

PROVIDER: PXD046630 | iProX | Wed May 21 00:00:00 BST 2025

REPOSITORIES: iProX

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Stage-dependent proteomic alterations in aqueous humor of diabetic retinopathy patients based on data-independent acquisition and parallel reaction monitoring.

Jin Yeanqi Y Liu Junbin J Zhang Xueli X Zhang Liang L Cui Ying Y Luo Xiaoyang X Zhu Haoxian H Chen Zhifan Z Liu Mengya M Wu Xiyu X Chen Xinyu X Liao Shuoxin S Wu Guanrong G Fang Xiang X Meng Qianli Q

Journal of translational medicine 20250425 1

<h4>Background</h4>Diabetic retinopathy (DR), a microvascular complication of diabetes mellitus (DM), represents the predominant cause of preventable vision loss in working-age populations globally. While the pathophysiological mechanisms underlying DR progression remain incompletely understood, our study employs comprehensive proteomic profiling of aqueous humor (AH) to identify stage-specific biomarkers and therapeutic targets in type 2 diabetes mellitus (T2DM) patients across DR progression.< ...[more]

PMID: 40281624

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