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Proteomics of malignant transformation of prostate WPMY-1 cells induced by arsenite

ABSTRACT: Proteomics of immortalized prostate myofibroblast cell line WPMY-1 treated by arsenite was performed and 517 differentially expressed proteins (DEPs) were identified.

ORGANISM(S): Homo Sapiens

SUBMITTER: Shan Wang

PROVIDER: PXD046880 | iProX | Fri Nov 10 00:00:00 GMT 2023

REPOSITORIES: iProX

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LCP1-mediated cytoskeleton alterations involve in arsenite-triggered malignant phenotype of human immortalized prostate stromal cells.

Yang Yiping Y Zhou Menghan M Huang Yurun Y Ye Xiaotong X Mo Yingxi Y Huang Yi Y Wang Shan S

Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 20240228

The connection between continuous arsenic exposure and prostate cancer is already established. However, the exact mechanisms of arsenic tumorigenesis are far from clear. Here, we employed human prostate stromal immortalized cells (WPMY-1) continuous exposure to 1 and 2 μM arsenite for 29 weeks to identify the malignant phenotype and explore the underlying molecular mechanism. As expected, continuous low-dose arsenite exposure led to the malignant phenotype of WPMY-1 cells. Quantitative proteomic ...[more]

PMID: 38417537

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