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Proteomic data of colon cancer cells treated with Benzosceptrin C for 12 hours

ABSTRACT: Cell samples were obtained from RKO treated with BC for 12 hours, and subsequent experiments were conducted after collecting the samples

ORGANISM(S): Homo Sapiens

SUBMITTER: Weidong Zhang

PROVIDER: PXD047186 | iProX | Wed Nov 22 00:00:00 GMT 2023

REPOSITORIES: iProX

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Benzosceptrin C induces lysosomal degradation of PD-L1 and promotes antitumor immunity by targeting DHHC3.

Wang Qun Q Wang Jinxin J Yu Dianping D Zhang Qing Q Hu Hongmei H Xu Mengting M Zhang Hongwei H Tian Saisai S Zheng Guangyong G Lu Dong D Hu Jiajia J Guo Mengmeng M Cai Minchen M Geng Xiangxin X Zhang Yanyan Y Xia Jianhua J Zhang Xing X Li Ang A Liu Sanhong S Zhang Weidong W

Cell reports. Medicine 20240117 2

Programmed cell death-1 (PD-1)/programmed cell death ligand-1 (PD-L1) blockade has become a mainstay of cancer immunotherapy. Targeting the PD-1/PD-L1 axis with small molecules is an attractive approach to enhance antitumor immunity. Here, we identified a natural marine product, benzosceptrin C (BC), that enhances the cytotoxicity of T cells to cancer cells by reducing the abundance of PD-L1. Furthermore, BC exerts its antitumor effect in mice bearing MC38 tumors by activating tumor-infiltrating ...[more]

PMID: 38237597

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