Proteomics

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The sequence of Fully Synthetic peptides, Phosphorylated Tau181, Tau217, and Tau231 Calibrators, have been confirmed by MALDI-ISD analysis

ABSTRACT: We designed novel calibrators that include three phosphorylated Tau sites: Tau (1-22)-pT231, Tau (1-22)-pT217, and Tau (1-22)-pT181, respectively. Our synthesized peptides have various advantages compared with GSK3β-phosphorylated Tau-441. The novel fully synthesized calibrators not only improved the precision and stability of immunoassays but also served as potential calibrators for the diagnosis of AD.

ORGANISM(S): Homo Sapiens

SUBMITTER: Zhicheng Chen  

PROVIDER: PXD047248 | iProX | Fri Nov 24 00:00:00 GMT 2023

REPOSITORIES: iProX

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Fully synthetic phosphorylated Tau181, Tau217, and Tau231 calibrators for Alzheimer's disease diagnosis.

Li Xinyu X   Zeng Huimei H   Durairaj Pradeepraj P   Wen Weihuan W   Li Tianpeng T   Zhao Yanru Y   Liu Yang Y   Liu Xue X   Zhan Lingpeng L   Rao Lang L   Yuan Wen W   Guo Tengfei T   Shen Weijun W   Cai Hui H   Chen Zhicheng Z  

Frontiers in aging neuroscience 20240115

<h4>Background</h4>The calibrator in immunoassay plays an essential role in diagnosing Alzheimer's disease (AD). Presently, the most well-studied biomarkers for AD diagnosis are three phosphorylated Tau (p-Tau): p-Tau231, p-Tau217, and p-Tau181. Glycogen synthase-3beta (GSK3β)-phosphorated Tau-441 is the most commonly used calibrator for p-Tau immunoassays. However, the batch-to-batch inconsistency issue of the commonly used GSK3β-phosphorylated Tau-441 limits its clinical application.<h4>Method  ...[more]

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