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Generation of a deep mouse brain spectral library for transmembrane proteome profiling in mental disease models

ABSTRACT: The establishment of a high-quality mouse brain transmembrane proteins spectral library enables in-depth profiling of the proteins across multiple brain regions. DIA data analysis, combining different search pipeline based on the spectral library, discovered a new GPCR regulator which was associated with depression verified via in vivo tests. This library represents a valuable resource that has the potential to discover the putative drug targets.

ORGANISM(S): Mus Musculus

SUBMITTER: Wenqing Shui

PROVIDER: PXD047251 | iProX | Sun Nov 26 00:00:00 GMT 2023

REPOSITORIES: iProX

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