Dataset Information
Circadian proteome atlas of wild-type and Per1-/-/Per2-/- mice models across eight organs
Ontology highlight
ABSTRACT:
ORGANISM(S): Mus Musculus
SUBMITTER: 
Tiannan Guo
PROVIDER: PXD047352 | iProX | Tue Nov 28 00:00:00 GMT 2023
REPOSITORIES: iProX
Publications
Multitissue Circadian Proteome Atlas of WT and Per1<sup>-/-</sup>/Per2<sup>-/-</sup> Mice.
Molecular & cellular proteomics : MCP 20231107 12
The molecular basis of circadian rhythm, driven by core clock genes such as Per1/2, has been investigated on the transcriptome level, but not comprehensively on the proteome level. Here we quantified over 11,000 proteins expressed in eight types of tissues over 46 h with an interval of 2 h, using WT and Per1/Per2 double knockout mouse models. The multitissue circadian proteome landscape of WT mice shows tissue-specific patterns and reflects circadian anticipatory phenomena, which are less obviou ...[more]
