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To explore the binding protein of HKDC1 by IP-MS

ABSTRACT: We used Hep3B cells expressing Flag tagged HKDC1 to explore the binding protein of HKDC1 by IP-MS

ORGANISM(S): Homo Sapiens

SUBMITTER: Ping Gao

PROVIDER: PXD047388 | iProX | Wed Nov 29 00:00:00 GMT 2023

REPOSITORIES: iProX

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HKDC1 promotes tumor immune evasion in hepatocellular carcinoma by coupling cytoskeleton to STAT1 activation and PD-L1 expression.

Zhang Yi Y Wang Mingjie M Ye Ling L Shen Shengqi S Zhang Yuxi Y Qian Xiaoyu X Zhang Tong T Yuan Mengqiu M Ye Zijian Z Cai Jin J Meng Xiang X Qiu Shiqiao S Liu Shengzhi S Liu Rui R Jia Weidong W Yang Xianzhu X Zhang Huafeng H Zhong Xiuying X Gao Ping P

Nature communications 20240213 1

Immune checkpoint blockade (ICB) has shown considerable promise for treating various malignancies, but only a subset of cancer patients benefit from immune checkpoint inhibitor therapy because of immune evasion and immune-related adverse events (irAEs). The mechanisms underlying how tumor cells regulate immune cell response remain largely unknown. Here we show that hexokinase domain component 1 (HKDC1) promotes tumor immune evasion in a CD8<sup>+</sup> T cell-dependent manner by activating STAT1 ...[more]

PMID: 38351096

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