Proteomics

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SARS-CoV-2-Infected hiPSC-Derived Cardiomyocytes Reveal Dynamic Changes in the COVID-19 Hearts

ABSTRACT: The ongoing coronavirus disease 2019 (COVID-19) pandemic has had an enormous impact on our societies. Moreover, the disease’s extensive and sustained symptoms are now becoming a nonnegligible medical challenge. In this respect, data show that heart failure is one of the most common readmission diagnoses among COVID-19 patients. In this study, we used human induced pluripotent stem cell (hiPSC)-derived cardiomyocytes to develop an in vitro severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection model and studied the dynamic changes occurring in cardiomyocytes after SARS-CoV-2 infection. Our findings highlight the importance of early detection and personalized treatment based on the disease stage. Finally, when our proteomics findings were combined with those of a virus-host interaction network analysis, we were able to identify several potential drug targets for the disease.

ORGANISM(S): Homo Sapiens

SUBMITTER: Ling Leng  

PROVIDER: PXD047427 | iProX | Fri Dec 01 00:00:00 GMT 2023

REPOSITORIES: iProX

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SARS-CoV-2-infected hiPSC-derived cardiomyocytes reveal dynamic changes in the COVID-19 hearts.

Li Xiao X   Hu Hengrui H   Liu Wanlin W   Zhang Qiyu Q   Wang Yujie Y   Chen Xingjuan X   Zhu Yunping Y   Hu Zhihong Z   Wang Manli M   Ma Jie J   Leng Ling L  

Stem cell research & therapy 20231212 1

<h4>Background</h4>The ongoing coronavirus disease 2019 (COVID-19) pandemic has had an enormous impact on our societies. Moreover, the disease's extensive and sustained symptoms are now becoming a nonnegligible medical challenge. In this respect, data indicate that heart failure is one of the most common readmission diagnoses among COVID-19 patients.<h4>Methods</h4>In this study, we used human induced pluripotent stem cell (hiPSC)-derived cardiomyocytes to develop an in vitro model of severe acu  ...[more]

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