Novel interacting proteins identified by tandem affinity purification and mass spectrometry associated with IFITM3 protein during PDCoV infection
Ontology highlight
ABSTRACT:
ORGANISM(S): Sus Scrofa Domesticus
SUBMITTER: 
Minghua Yan
PROVIDER: PXD047480 | iProX | Sat Dec 02 00:00:00 GMT 2023
REPOSITORIES: iProX
Publications
Novel interacting proteins identified by tandem affinity purification and mass spectrometry associated with IFITM3 protein during PDCoV infection.
Li Cheng C Guo Xiao-Ran XR Dong Zhi-Min ZM Gao Yu-Jin YJ Li Xiu-Li XL Zhang Li L Zheng Hong-Qing HQ Wang Li-Li LL Lu Chao C Tian Xiang-Xue XX Yan Ming-Hua MH
International journal of biological macromolecules 20240529 Pt 2
Interferon-induced transmembrane 3 (IFITM3) is a membrane-associated protein that exhibits antiviral activities against a wide range of viruses through interactions with other cellular and viral proteins. However, knowledge of the mechanisms of IFITM3 in Porcine deltacoronavirus (PDCoV) infection has been lacking. In this study, we demonstrate that IFN-α treatment induces the upregulation of IFITM3 activity and thus attenuates PDCoV infection. PDCoV replication is inhibited in a dose-dependent m ...[more]
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