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Mass spec results of CSN-FBP project

ABSTRACT: This project amis to elucidate the mechanism by which CSN regulates the assembly of SCF complex.

ORGANISM(S): Arabidopsis Thaliana

SUBMITTER: Jie Dong

PROVIDER: PXD047481 | iProX | Tue Dec 05 00:00:00 GMT 2023

REPOSITORIES: iProX

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COP9 signalosome-mediated deneddylation of CULLIN1 is necessary for SCF<sup>EBF1</sup> assembly in Arabidopsis thaliana.

Dong Jie J Dong Jie J Li Yuanyuan Y Cheng Shuyang S Li Xuehui X Wei Ning N

Cell reports 20240106 1

Functions of the SKP1-CUL1-F box (SCF) ubiquitin E3 ligases are essential in plants. The F box proteins (FBPs) are substrate receptors that recruit substrates and assemble an active SCF complex, but the regulatory mechanism underlying the FBPs binding to CUL1 to activate the SCF cycle is not fully understood. We show that Arabidopsis csn1-10 is defective in SCF<sup>EBF1</sup>-mediated PIF3 degradation during de-etiolation, due to impaired association of EBF1 with CUL1 in csn1-10. EBF1 preferenti ...[more]

PMID: 38184853

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