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Mesenteric Adipose-Derived Exosomal TINAGL1 Enhances Intestinal Fibrosis in Crohn's Disease via SMAD4

ABSTRACT: Intestinal fibrosis, a severe complication in Crohn's Disease (CD), significantly impairs patient quality of life and lacks clear molecular understanding. Emerging evidence suggests a crucial role for mesenteric adipose tissue (MAT) in CD pathophysiology, particularly through its exosome secretion, which may modulate fibrogenic pathways. This study focuses on elucidating the role of MAT-derived exosomes in CD-related fibrosis, emphasizing their molecular composition and potential impact on disease progression.

ORGANISM(S): Mus Musculus

SUBMITTER: Liangru Zhu

PROVIDER: PXD047519 | iProX | Mon Dec 04 00:00:00 GMT 2023

REPOSITORIES: iProX

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