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A proximity interactome assay for interaction of nipah virus F and G protein with the cellular protein

ABSTRACT: Nipah virus (NiV) is a highly lethal zoonotic virus with a potential large-scale outbreak, which poses a great threat to world health and security. Cell entry is the first step in viral infection, and the entry of NiV into host cells is inseparable from the attachment (G) and fusion (F) glycoproteins. To discover the host factors potentially involved in the entry of NiV into host cells, we systematically studied the interaction of NiV F and G proteins with host proteins using proximity labeling methods.

ORGANISM(S): Homo Sapiens

SUBMITTER: Chang Li

PROVIDER: PXD048109 | iProX | Fri Dec 22 00:00:00 GMT 2023

REPOSITORIES: iProX

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Interaction of Nipah Virus F and G with the Cellular Protein Cortactin Discovered by a Proximity Interactome Assay.

Cui Chunmei C Hao Pengfei P Jin Chaozhi C Xu Wang W Liu Yuchen Y Li Letian L Du Shouwen S Shang Limin L Jin Xin X Jin Ningyi N Wang Jian J Li Chang C

International journal of molecular sciences 20240408 7

Nipah virus (NiV) is a highly lethal zoonotic virus with a potential large-scale outbreak, which poses a great threat to world health and security. In order to explore more potential factors associated with NiV, a proximity labeling method was applied to investigate the F, G, and host protein interactions systematically. We screened 1996 and 1524 high-confidence host proteins that interacted with the NiV fusion (F) glycoprotein and attachment (G) glycoprotein in HEK293T cells by proximity labeli ...[more]

PMID: 38612921

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