Proteomics

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Thermal proteome profiling reveals fructose-1,6-bisphosphate as a phosphate donor to activate phosphoglycerate mutase 1


ABSTRACT: Collectively we have profiled a spectrum of sugar metabolite-interaction proteins, and discovered a unique signaling effect of FBP that supports Warburg effect in cancer cells via a histidine phosphorylation of PGAM1, which inspires the development of therapeutic tools of interrupting cancer cell metabolism.

ORGANISM(S): Homo Sapiens

SUBMITTER: Yiqun Geng  

PROVIDER: PXD048243 | iProX | Thu Jan 04 00:00:00 GMT 2024

REPOSITORIES: iProX

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