Integrated Single-Cell Proteomics Analysis on an Active Matrix Digital Microfluidic Chip
Ontology highlight
ABSTRACT:
ORGANISM(S): Homo Sapiens
SUBMITTER: 
Hu Zhou
PROVIDER: PXD048434 | iProX | Mon Apr 15 00:00:00 BST 2024
REPOSITORIES: iProX
Publications
AM-DMF-SCP: Integrated Single-Cell Proteomics Analysis on an Active Matrix Digital Microfluidic Chip.
Yang Zhicheng Z Jin Kai K Chen Yimin Y Liu Qian Q Chen Hongxu H Hu Siyi S Wang Yuqiu Y Pan Zilu Z Feng Fang F Shi Mude M Xie Hua H Ma Hanbin H Zhou Hu H
JACS Au 20240326 5
Single-cell proteomics offers unparalleled insights into cellular diversity and molecular mechanisms, enabling a deeper understanding of complex biological processes at the individual cell level. Here, we develop an integrated sample processing on an active-matrix digital microfluidic chip for single-cell proteomics (AM-DMF-SCP). Employing the AM-DMF-SCP approach and data-independent acquisition (DIA), we identify an average of 2258 protein groups in single HeLa cells within 15 min of the liquid ...[more]
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