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SOCS5-RBMX stimulates SREBP1-mediated lipogenesis to promote metastasis in HCC

ABSTRACT: SOCS5 stimulate the promoter of SREBP1 to induce de novo lipogenesis to promote HCC metastasis

ORGANISM(S): Homo Sapiens

SUBMITTER: Yongru Yao

PROVIDER: PXD048740 | iProX | Mon Jan 22 00:00:00 GMT 2024

REPOSITORIES: iProX

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SOCS5-RBMX stimulates SREBP1-mediated lipogenesis to promote metastasis in steatotic HCC with HBV-related cirrhosis.

Wang Youpeng Y Zhao Ziyin Z Guo Tingting T Wu Tiansong T Zhang Mao M Luo Dingan D Dou Kunpeng K Yang Yeni Y Jin Cheng C Zhang Bingyuan B Zhang Bin B Han Bing B

NPJ precision oncology 20240301 1

Abnormal lipid metabolism promotes hepatocellular carcinoma (HCC) progression, which engenders therapeutic difficulties owing to unclear mechanisms of the phenomenon. We precisely described a special steatotic HCC subtype with HBV-related cirrhosis and probed its drivers. Hematoxylin-eosin (HE) staining of 245 HCC samples revealed a special HCC subtype (41 cases) characterized by HBV-related cirrhosis and intratumoral steatosis without fatty liver background, defined as steatotic HCC with HBV-re ...[more]

PMID: 38429411

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