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Serum Metabolomics in Patients with Ocular Diseases

ABSTRACT: Serum metabolomics in patients with ocular diseases is a fascinating and emerging field of study. It involves analyzing the metabolites in blood serum to understand the biochemical processes and pathways associated with various eye conditions. This approach provides a deeper insight into the pathophysiology of ocular diseases and can lead to novel diagnostic and therapeutic strategies.

ORGANISM(S): Homo Sapiens

SUBMITTER: Wenjun Cao

PROVIDER: PXD048826 | iProX | Wed Jan 24 00:00:00 GMT 2024

REPOSITORIES: iProX

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Metabolomics identifies and validates serum androstenedione as novel biomarker for diagnosing primary angle closure glaucoma and predicting the visual field progression.

Li Shengjie S Ren Jun J Jiang Zhendong Z Qiu Yichao Y Shao Mingxi M Li Yingzhu Y Wu Jianing J Song Yunxiao Y Sun Xinghuai X Gao Shunxiang S Cao Wenjun W

eLife 20240215

<h4>Background</h4>Primary angle closure glaucoma (PACG) is the leading cause of irreversible blindness in Asia, and no reliable, effective diagnostic, and predictive biomarkers are used in clinical routines. A growing body of evidence shows metabolic alterations in patients with glaucoma. We aimed to develop and validate potential metabolite biomarkers to diagnose and predict the visual field progression of PACG.<h4>Methods</h4>Here, we used a five-phase (discovery phase, validation phase 1, va ...[more]

PMID: 38358793

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