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The role of CD11c in dendritic cells

ABSTRACT: We cultured bone marrow derived dendritic cells from WT and CD11c KO mice. Then, a group of bone marrow dendritic cells were stimulated with LPS overnight. We obtained bone marrow derived dendritic cells with or without LPS stimulation and analyzed proteomics profiles.

ORGANISM(S): Mus Musculus

SUBMITTER: Koichi Yuki

PROVIDER: PXD048907 | iProX | Fri Jan 26 00:00:00 GMT 2024

REPOSITORIES: iProX

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Integrin CD11c regulates B cell homeostasis.

Hou Lifei L Sin Yi-Cheng YC Chen Yue Y Yuki Koichi K

Frontiers in immunology 20240206

CD11c is widely known as a cell surface marker for dendritic cells, but we recently showed that it regulates neutrophil and T cell functions. Because we found that CD11c knockout (KO) mice had lower blood B cell counts, we characterized B cell profile in developmental stages. We found that CD11c KO recirculating and mature B cells was significantly fewer compared with wild type, associated with exaggerated proliferation and apoptosis. Because they did not express CD11c, we sought for the possibi ...[more]

PMID: 38380335

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