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Quantitative Pattern of hPTMs by Mass Spectrometry-based Proteomics with Implications for Triple-Negative Breast Cancer

ABSTRACT: Triple-negative breast cancer (TNBC) is characterized by its aggressive behavior, with trend to early relapse and metastasis as well as poor survival. Limited therapies and lack of effective therapeutic targets are one of the main challenges in clinical management of TNBC. Histone post-translational modifications (hPTMs) have been implicated in breast cancer. However, rare information on the association between hPTMs and molecular subtypes of breast cancer can be found so far.

ORGANISM(S): Homo Sapiens

SUBMITTER: Yun Chen

PROVIDER: PXD049101 | iProX | Thu Feb 01 00:00:00 GMT 2024

REPOSITORIES: iProX

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Quantitative Pattern of hPTMs by Mass Spectrometry-Based Proteomics with Implications for Triple-Negative Breast Cancer.

Liu Chunyan C Xu Mengying M Li Wan W Cao Xiao X Wang Yan Y Chen Haoran H Zhang Tianqi T Lu Meiyan M Xie Hui H Chen Yun Y

Journal of proteome research 20240305 4

Triple-negative breast cancer (TNBC) is known for its aggressive nature, and TNBC management is currently challenging due to the lack of effective targets. Despite the importance of histone post-translational modifications (hPTMs) in breast cancer, their associations with molecular subtypes of breast cancer, especially TNBC, are poorly understood. In this study, a combination of untargeted and targeted proteomics approaches, supplemented by a derivatization method, was applied to breast cancer c ...[more]

PMID: 38576392

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