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Proteomic analysis of DEN and CCl4-induced hepatocellular carcinoma mouse model

ABSTRACT: DEN and CCl4-induced HCC mouse model was constructed, and the proteome of HCC and liver tissues was analyzed.

ORGANISM(S): Mus Musculus

SUBMITTER: Ying Jiang

PROVIDER: PXD049148 | iProX | Sun Feb 04 00:00:00 GMT 2024

REPOSITORIES: iProX

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Proteomic analysis of DEN and CCl<sub>4</sub>-induced hepatocellular carcinoma mouse model.

Zhang Qian Q Liu Yuhui Y Ren Liangliang L Li Junqing J Lin Weiran W Lou Lijuan L Wang Minghan M Li Chaoying C Jiang Ying Y

Scientific reports 20240405 1

Hepatocellular carcinoma (HCC) seriously threatens human health, mostly developed from liver fibrosis or cirrhosis. Since diethylnitrosamine (DEN) and carbon tetrachloride (CCl<sub>4</sub>)-induced HCC mouse model almost recapitulates the characteristic of HCC with fibrosis and inflammation, it is taken as an essential tool to investigate the pathogenesis of HCC. However, a comprehensive understanding of the protein expression profile of this model is little. In this study, we performed proteomi ...[more]

PMID: 38580754

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