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4D label-free quantitative proteomics analysis of collagen-induced arthritis rats

ABSTRACT: 4D label-free quantitative proteomics was performed to analysis the changes of protein expression in synovial tissues between Normal control group, Model control group and JTQBG treated group.

ORGANISM(S): Rattus Norvegicus

SUBMITTER: Qiuai Kou

PROVIDER: PXD050056 | iProX | Fri Feb 23 00:00:00 GMT 2024

REPOSITORIES: iProX

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The protective effect of traditional Chinese medicine Jinteng Qingbi granules on rats with rheumatoid arthritis.

Wan Yingying Y Sun Wenting W Yang Jiaxi J Wang Haonan H Wang Wenqian W Ye Wanting W Cheng Guoliang G Li Bing B Ren Jianxun J Kou Qiuai Q

Frontiers in pharmacology 20240313

<b>Introduction:</b> Jinteng Qingbi granules (JTQBG), a traditional Chinese medicine formulation, are widely used for the treatment of rheumatoid arthritis (RA) due to their satisfactory therapeutic efficacy. However, the underlying mechanism of action remains unclear. This study aims to investigate the protective effects of JTQBG against RA and elucidates its potential molecular mechanisms. <b>Methods:</b> A collagen-induced arthritis (CIA) rat model was utilized, and JTQBG (1.25, 2.5, 5 g/kg/d ...[more]

PMID: 38545550

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