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Global profiling of lysine ubiquitylation in human hypothalamus

ABSTRACT: In this study, we employed LC‒MS/MS to generate a comprehensive profile of ubiquitylation in the human hypothalamus under normal physiological conditions. Our findings will contribute to further exploration of the role of ubiquitylation in various physiological and pathological processes, particularly the molecular mechanisms underlying cellular processes in the hypothalamus.

ORGANISM(S): Homo Sapiens

SUBMITTER: Juntao Yang

PROVIDER: PXD050124 | iProX | Sat Feb 24 00:00:00 GMT 2024

REPOSITORIES: iProX

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Global Profiling of Lysine Ubiquitylation in the Human Hypothalamus.

Zhang Zhi-Yi ZY Ding Tao T Kong Jie J Wang Qiao-Chu QC Zhang Xu-Tong XT Shi Chun-Mei CM Yang Jun-Tao JT Liu Jiang-Feng JF

Proteomics. Clinical applications 20251109 1

<h4>Purpose</h4>Ubiquitylation is a vital post-translational modification involved in various biological processes, yet its role in the human hypothalamus remains largely unexplored. This study aims to profile the ubiquitinome of the human hypothalamus, uncovering the ubiquitylation landscape and its potential implications in hypothalamic function.<h4>Experimental design</h4>We employed LC‒MS/MS to analyze hypothalamic tissues from six healthy elderly individuals, focusing on identifying and cha ...[more]

PMID: 41208143

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