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Proteome and lipidome of Urine-derived Exosomes in Mycobacterium tuberculosis Infected Patients

ABSTRACT: This study confirmed the aberrant lipids and protein spectrum in exosomes of Mtb infected individuals, uncovered novel potential lipid biomarkers for TB/LTBI diagnosis and revealed integral role of exosomal lipid-raft-dependent biological processes in TB pathogenesis.

ORGANISM(S): Homo Sapiens

SUBMITTER: Huiguo Ding

PROVIDER: PXD050345 | iProX | Mon Mar 04 00:00:00 GMT 2024

REPOSITORIES: iProX

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Individualized lipid profile in urine-derived extracellular vesicles from clinical patients with <i>Mycobacterium tuberculosis</i> infections.

Lyu Lingna L Jia Hongyan H Liu Qiuyue Q Ma Wenxia W Li Zihui Z Pan Liping L Zhang Xiuli X

Frontiers in microbiology 20240530

<h4>Background</h4>Lipids are a key nutrient source for the growth and reproduction of <i>Mycobacterium tuberculosis</i> (<i>Mtb</i>). Urine-derived extracellular vesicles (EVs), because of its non-invasive sampling, lipid enrichment, and specific sorting character, have been recognized as a promising research target for biomarker discovery and pathogenesis elucidation in tuberculosis (TB). We aim to profile lipidome of <i>Mtb</i>-infected individuals, offer novel lipid signatures for the develo ...[more]

PMID: 38873163

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