Mass spectrometry of HCT116 cells
Ontology highlight
ABSTRACT:
ORGANISM(S): Homo Sapiens
SUBMITTER: 
Zhengquan Yu
PROVIDER: PXD050513 | iProX | Sat Mar 09 00:00:00 GMT 2024
REPOSITORIES: iProX
Publications
ROS-induced cytosolic release of mitochondrial PGAM5 promotes colorectal cancer progression by interacting with MST3.
Wang Shiyang S Wu Xi X Bi Wenxin W Xu Jiuzhi J Hou Liyuan L Li Guilin G Pan Yuwei Y Zhang Hanfu H Li Mengzhen M Du Sujuan S Zhang Mingxin M Liu Di D Jin Shuiling S Shi Xiaojing X Tian Yuhua Y Shuai Jianwei J Plikus Maksim V MV Song Moshi M Zhou Zhaocai Z Yu Lu L Lv Cong C Yu Zhengquan Z
Nature communications 20250206 1
Aberrant release of mitochondrial reactive oxygen species (mtROS) in response to cellular stress is well known for promoting cancer progression. However, precise molecular mechanism by which mtROS contribute to epithelial cancer progression remains only partially understood. Here, using colorectal cancer (CRC) models, we show that upon sensing excessive mtROS, phosphatase PGAM5, which normally localizes to the mitochondria, undergoes aberrant cleavage by presenilin-associated rhomboid-like prote ...[more]
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