Establishment of a new isolation method for urinary exosomes
Ontology highlight
ABSTRACT:
ORGANISM(S): Homo Sapiens
SUBMITTER: 
Haifang Yin
PROVIDER: PXD050607 | iProX | Thu Mar 14 00:00:00 GMT 2024
REPOSITORIES: iProX
Publications
Differentiation of high risk prostate cancer with a facile urinary exosome detection workflow.
Qiu Shuai S Li Yue Y Zhang Zheng Z Li Chunchang C Wang Haoyu H Chen Ao A Yan Zhi Z Liu Yang Y Li Zifei Z Huang Hua H Liu Yi Y Seow Yiqi Y Chen Ruibing R Guo Jinhong J Wen Simeng S Tian Jing J Zhang Hongtuan H Liu Ranlu R Han Gang G Wang Baolong B Wang Yong Y Niu Yuanjie Y Yin HaiFang H
iScience 20250127 2
Clear differentiation of high-grade and clinically insignificant prostate cancer (PCa) is critical for clinical decision-making. Here, we developed a proprietary urinary exosome isolation approach (EVLatch) and established a facile diagnostic workflow. We discovered that <i>EEF1A1</i> levels, abundantly expressed on urinary exosomes, positively correlate to urinary exosome counts irrespective of source and collection time and demonstrated that <i>EEF1A1</i> enables in-assay quantification of uri ...[more]
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