Proteomics

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Proteomic of control and FBL knockdown C4-2 cells

ABSTRACT: We employed a quantitative proteomics approach to compare the protein expression levels between control and FBL knockdown C4-2 cells, revealing expression levels of some proteins which have decreased mRNA half-life.

ORGANISM(S): Homo Sapiens

SUBMITTER: Kaifu Chen  

PROVIDER: PXD050701 | iProX | Sun Mar 17 00:00:00 GMT 2024

REPOSITORIES: iProX

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Publications

2'-O-methylation at internal sites on mRNA promotes mRNA stability.

Li Yanqiang Y   Yi Yang Y   Gao Xinlei X   Wang Xin X   Zhao Dongyu D   Wang Rui R   Zhang Li-Sheng LS   Gao Boyang B   Zhang Yadong Y   Zhang Lili L   Cao Qi Q   Chen Kaifu K  

Molecular cell 20240601 12

2'-O-methylation (Nm) is a prominent RNA modification well known in noncoding RNAs and more recently also found at many mRNA internal sites. However, their function and base-resolution stoichiometry remain underexplored. Here, we investigate the transcriptome-wide effect of internal site Nm on mRNA stability. Combining nanopore sequencing with our developed machine learning method, NanoNm, we identify thousands of Nm sites on mRNAs with a single-base resolution. We observe a positive effect of F  ...[more]

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