SUMOylation-Induced Membrane Localization of TRPV1 Suppresses Proliferation and Migration in Gastric Cancer Cells

ABSTRACT: In this work, we elucidate a novel mechanism wherein TRPV1 SUMOylation promotes its membrane expression and activates the TRPV1-Ca2+-AMPK signaling pathway, thereby inhibiting GC cell proliferation and migration. These findings enhance our understanding of the molecular dynamics in gastric cancer and could provide a new theoretical basis for clinical treatment strategies.

ORGANISM(S): Homo Sapiens

SUBMITTER: Yang Yang  

PROVIDER: PXD050942 | iProX | Mon Mar 25 00:00:00 GMT 2024

REPOSITORIES: iProX