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Toxicological safety evaluation of diallyl trisulfide through acute and subacute toxicity studies in ICR mice

ABSTRACT: Diallyl trisulfide (DATS) is one of the main sulfide-containing compounds in garlic oil and has been shown to have a variety of biological activities such as anti-tumor, inhibition of inflammation, and immune regulation. However, there is very little information available regarding its toxicological safety. To elucidate the toxicity mechanism and find the early warning biomarker of DATS, this study conducted acute and subacute toxicity experiments according to the OECD guidelines. The potential serum biomarker and toxicity mechanism of DATS were explored by proteomics.

ORGANISM(S): Mus Musculus

SUBMITTER: Yue Gao

PROVIDER: PXD051045 | iProX | Thu Mar 28 00:00:00 GMT 2024

REPOSITORIES: iProX

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Safety assessment and exploration of the mechanism of toxic effects of diallyl trisulfide: Based on acute and subacute toxicity and proteomics experiments.

Wu Zhenhui Z Tu Bodan B Li Shubei S Chen Junru J Shen Pan P Zhou Wei W Ma Zengchun Z Tang Xianglin X Xiao Chengrong C Wang Yihao Y Gao Yue Y

Journal of ethnopharmacology 20241113 Pt 3

<h4>Ethnopharmacological relevance</h4>Garlic (Allium sativum L.) is a widely consumed spice and condiment around the world, applied both as a food and as a traditional medicine, and is a natural strengthening agent for the body's circulatory and nervous systems. Diallyl trisulfide (DATS) is the major volatile organosulfur phytochemical found in garlic, with antithrombotic, anticoagulant, and antiplatelet activities as well as antioxidant, anti-infective, and other pharmacological effects. Howev ...[more]

PMID: 39542188

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