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Synergistic Therapeutic Effects of D-Mannitol-Cerium-Quercetin (Rutin) Coordination Polymer Nanoparticles on Acute Lung Injury

ABSTRACT: In our latest study, we pioneered the use of D-Mannitol-Cerium-Quercetin/Rutin coordination polymer nanoparticles (MCQ/R NPs) as a potential remedy for ALI. our in vivo studies with LPS-induced ALI mice showed significant mitigation of lung tissue inflammation. This groundbreaking research presents MCQ/R NPs as a prospective vanguard in ALI therapeutics by proteomics.

ORGANISM(S): Mus Musculus

SUBMITTER: Xianyu Li

PROVIDER: PXD051350 | iProX | Wed Apr 10 00:00:00 BST 2024

REPOSITORIES: iProX

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Synergistic Therapeutic Effects of D-Mannitol-Cerium-Quercetin (Rutin) Coordination Polymer Nanoparticles on Acute Lung Injury.

Zhang Yusheng Y Wang Hong H Yang Ruiying R Zhang Ying Y Chen Yao Y Jiang Cuiping C Li Xianyu X

Molecules (Basel, Switzerland) 20240613 12

Acute lung injury (ALI) remains a significant global health issue, necessitating novel therapeutic interventions. In our latest study, we pioneered the use of D-mannitol-cerium-quercetin/rutin coordination polymer nanoparticles (MCQ/R NPs) as a potential treatment for ALI. The MCQ/R NPs, which integrate rutin and quercetin for their therapeutic potential and D-mannitol for its pulmonary targeting, displayed exceptional efficacy. By utilizing cerium ions for optimal nanoparticle assembly, the MCQ ...[more]

PMID: 38930884

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