Proteomics

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Temperature-assisted limited proteolysis-coupled mass spectrometry approach to identify drug targets and binding sites in complex proteomes


ABSTRACT: Drug target identification is an important premise of drug discovery and their mechanism investigation. In this study, we developed a temperature-assisted limited proteolysis-coupled mass spectrometry (TALiP-MS) method to systematically study drug binding targets and binding sites at the proteome level. We have proved that TALiP-MS was suitable for a variety of ligands, including cyclosporin A, geldanamycin and staurosporine.

ORGANISM(S): Homo Sapiens

SUBMITTER: Wen Gao  

PROVIDER: PXD051811 | iProX | Fri Apr 26 00:00:00 BST 2024

REPOSITORIES: iProX

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