Proteomics

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The involvement of autophagy in mesaconitine-induced neurotoxicity in HT22 cells revealed through integrated transcriptomic, proteomic, and m6A epitranscriptomic profiling

ABSTRACT: In order to investigate the effects of mesaconitine treatment on protein expression, we carried out quantitative proteomic analysis to elucidate comprehensive protein changes in HT22 cells with or without mesaconitine treatment.

ORGANISM(S): Mus Musculus

SUBMITTER: An Zhu  

PROVIDER: PXD052001 | iProX | Fri May 03 00:00:00 GMT+01:00 2024

REPOSITORIES: iProX

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Involvement of autophagy in mesaconitine-induced neurotoxicity in HT22 cells revealed through integrated transcriptomic, proteomic, and m6A epitranscriptomic profiling.

Lin Xiaohuang X   Zhang Jian J   Wu Zekai Z   Shi Yuan Y   Chen Mengting M   Li Maodong M   Hu Hong H   Tian Kun K   Lv Xiaoqi X   Li Chutao C   Liu Yang Y   Gao Xinyue X   Yang Qiaomei Q   Chen Kunqi K   Zhu An A  

Frontiers in pharmacology 20240613

<b>Background:</b> Mesaconitine (MA), a diester-diterpenoid alkaloid extracted from the medicinal herb <i>Aconitum carmichaelii</i>, is commonly used to treat various diseases. Previous studies have indicated the potent toxicity of aconitum despite its pharmacological activities, with limited understanding of its effects on the nervous system and the underlying mechanisms. <b>Methods:</b> HT22 cells and zebrafish were used to investigate the neurotoxic effects of MA both <i>in vitro</i> and <i>i  ...[more]

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