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The effects of Cas5 on the protein biosynthesis of Candida albicans

ABSTRACT: Cas5, a transcriptional regulator of Candida albicans, has profound effects on the biosynthesis of cell wall proteins through regulating Candida albicans cell wall remodeling

ORGANISM(S): Candida Albicans

SUBMITTER: Jiye Zhang

PROVIDER: PXD052043 | iProX | Tue May 07 00:00:00 BST 2024

REPOSITORIES: iProX

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Cas5 Regulates the Exposure of β-Glucan, the Cell Surface Hydrophobicity, and the Expression of Cell Wall Proteins to Remodel the Candida albicans Cell Wall and Participates in the Recruitment of Neutrophils.

Zhang Qiyue Q Li Guanglin G Wang Yanmei Y Yang Chen C Bai Wenhui W Li Qingqing Q Zhang Jiye J Zhang Peipei P

Microorganisms 20250319 3

Candida albicans (C. albicans) is a major opportunistic fungal pathogen that causes life-threatening infections, particularly in immunocompromised individuals, underscoring the critical need to understand its pathogenic mechanisms. This study investigates the role of Cas5, a key transcription factor, in regulating C. albicans cell wall remodeling, virulence, and host interactions. Genetic manipulation and biochemical assays were used to examine the effects of Cas5 depletion ...[more]

PMID: 40142575

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