RHOF Activation of AKT/β-Catenin Signaling Pathway Drives Acute Myeloid Leukemia Progression and Chemotherapy Resistance
Ontology highlight
ABSTRACT:
ORGANISM(S): Homo Sapiens
SUBMITTER: 
Chunyan Ji
PROVIDER: PXD052126 | iProX | Thu May 09 00:00:00 BST 2024
REPOSITORIES: iProX
Publications
RHOF activation of AKT/β-catenin signaling pathway drives acute myeloid leukemia progression and chemotherapy resistance.
Wen Xin X Li Peng P Ma Yuechan Y Wang Dongmei D Jia Ruinan R Xia Yuan Y Li Wei W Li Yongjian Y Li Guosheng G Sun Tao T Lu Fei F Ye Jingjing J Ji Chunyan C
iScience 20240608 7
Acute myeloid leukemia (AML) is a clonal malignancy originating from leukemia stem cells, characterized by a poor prognosis, underscoring the necessity for novel therapeutic targets and treatment methodologies. This study focuses on Ras homolog family member F, filopodia associated (RHOF), a Rho guanosine triphosphatase (GTPase) family member. We found that RHOF is overexpressed in AML, correlating with an adverse prognosis. Our gain- and loss-of-function experiments revealed that RHOF overexpre ...[more]
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