Mass Spectrometry analysis of potential proteins interacting with cyclin D1 mutants (T286A or T288A)
Ontology highlight
ABSTRACT:
ORGANISM(S): Homo Sapiens
SUBMITTER: 
Haojun Xiong
PROVIDER: PXD052332 | iProX | Fri May 17 00:00:00 BST 2024
REPOSITORIES: iProX
Publications
F-box protein FBXO32 ubiquitinates and stabilizes D-type cyclins to drive cancer progression.
Li Feng F Yu Hongqiang H Zhang Yujun Y Ma Yuanhang Y Chen Xinlei X Zhang Jie J Sun Liangbo L Guo Rui R Wu Ying Y Zheng Ping P Wang Xiaojun X Bie Ping P He Fengtian F Zhang Leida L Xie Chuanming C Xiong Haojun H
Nature communications 20250430 1
D-type cyclins (hereafter, cyclin D) are central regulators orchestrating G1/S cell cycle transition. Accordingly, aberrant expression of cyclin D is strongly correlated with proliferation-related diseases such as cancer. However, the mechanisms regulating cyclin D turnover are incompletely elucidated. Here we identify FBXO32, namely atrogin-1, as the E3 ubiquitin ligase that targets all three cyclin D for ubiquitination and stabilization. Specifically, FBXO32 catalyzes the lysine (Lys/K)27-link ...[more]
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