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Translocational attenuation regulated by PERK-SRP14 axis is a novel protective mechanism of UPR

ABSTRACT: Translocational attenuation regulated by PERK-SRP14 axis is a novel protective mechanism of UPR

ORGANISM(S): Homo Sapiens

SUBMITTER: Yili Yang

PROVIDER: PXD052453 | iProX | Wed May 22 00:00:00 BST 2024

REPOSITORIES: iProX

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Translocational attenuation mediated by the PERK-SRP14 axis is a protective mechanism of unfolded protein response.

Liu Yaofu Y Gu Yuexi Y Chen Ying Y Wang Xuan X Zhou Guangfeng G Li Jing J Wang Mu M Fang Shengyun S Yang Yili Y

Cell reports 20240627 7

The unfolded protein response (UPR) relieves endoplasmic reticulum (ER) stress through multiple strategies, including reducing protein synthesis, increasing protein folding capabilities, and enhancing misfolded protein degradation. After a multi-omics analysis, we find that signal recognition particle 14 (SRP14), an essential component of the SRP, is markedly reduced in cells undergoing ER stress. Further experiments indicate that SRP14 reduction requires PRKR-like ER kinase (PERK)-mediated euka ...[more]

PMID: 38943644

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