Proteomics

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A proteomic analysis of plasma using data-independent acquisition approach to explore infantile epileptic spasm syndrome

ABSTRACT: Infantile epileptic spasm syndrome (IESS) presents a significant challenge in pediatric neurology due to its potential for progressive cognitive and behavioral impairments. This study aimed to shed light on the pathogenesis of IESS through a comprehensive proteomic analysis of plasma samples using data-independent acquisition (DIA) methodology. This research was supposed to provide valuable insights into the pathogenesis of IESS and offers a basis for future studies focusing on personalized therapeutic approaches.

ORGANISM(S): Homo Sapiens

SUBMITTER: Dongfang Zou  

PROVIDER: PXD052465 | iProX | Wed May 22 00:00:00 GMT+01:00 2024

REPOSITORIES: iProX

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Exploring Infantile Epileptic Spasm Syndrome: A Proteomic Analysis of Plasma Using the Data-Independent Acquisition Approach.

Huang Haohua H   Cao Dezhi D   Hu Yan Y   He Qianqian Q   Zhao Xia X   Chen Li L   Lin Sufang S   Luo Xufeng X   Ye Yuanzhen Y   Liao Jianxiang J   Zou Huafang H   Zou Dongfang D  

Journal of proteome research 20240610 10

This study aimed to identify characteristic proteins in infantile epileptic spasm syndrome (IESS) patients' plasma, offering insights into potential early diagnostic biomarkers and its underlying causes. Plasma samples were gathered from 60 patients with IESS and 40 healthy controls. Data-independent acquisition proteomic analysis was utilized to identify differentially expressed proteins (DEPs). These DEPs underwent functional annotation through Gene Ontology (GO) and the Kyoto Encyclopedia of  ...[more]

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