Profiling of the proteins interacting with amyloid beta peptides in clinical samples by PACTS-TPP
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ABSTRACT:
ORGANISM(S): Homo Sapiens
SUBMITTER: 
Chenxi Jia
PROVIDER: PXD052500 | iProX | Thu May 23 00:00:00 BST 2024
REPOSITORIES: iProX
Publications
Profiling of the Proteins Interacting with Amyloid Beta Peptides in Clinical Samples by PACTS-TPP.
Xu Mengting M Wang Xiankun X Zhang Yang Y Ji Nan N Wang Qianqian Q Zhao Ting T Zhou Congli C Jia Chenxi C
Journal of the American Society for Mass Spectrometry 20240523 6
The accumulation of amyloid beta (Aβ1-42) results in neurotoxicity and is strongly related to neurodegenerative disorders, especially Alzheimer's disease (AD), but the underlying molecular mechanism is still poorly understood. Therefore, there is an urgent need for researchers to discover the proteins that interact with Aβ1-42 to determine the molecular basis. Previously, we developed peptide-ligand-induced changes in the abundance of proTeinS (PACTS)-assisted thermal proteome profiling (TPP) to ...[more]
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