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Falcon Probe: A High-Pressure and Robust Sampling Interface for Coupling Lossless Liquid Chromatography Injection with In-Situ Nanoliter-Scale Sample Pretreatment

ABSTRACT: HeLa protein digest and single 293 cell proteome data analyzed by the Falcon probe-based LC-MS analysis system.

ORGANISM(S): Homo Sapiens

SUBMITTER: Qun Fang

PROVIDER: PXD052544 | iProX | Fri May 24 00:00:00 BST 2024

REPOSITORIES: iProX

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Falcon Probe: A High-Pressure and Robust Sampling Interface for Coupling Lossless Liquid Chromatography Injection with In Situ Nanoliter-Scale Sample Pretreatment.

Ying Wei-Xin WX Shi Shao-Wen SW Wang Hui-Feng HF Chen Jian-Bo JB Pan Jian-Zhang JZ Fang Qun Q

Analytical chemistry 20240729 32

With the increasing demand for trace sample analysis, injecting trace samples into liquid chromatography-mass spectrometry (LC-MS) systems with minimal loss has become a major challenge. Herein, we describe an in situ LC-MS analytical probe, the Falcon probe, which integrates multiple functions of high-pressure sample injection without sample loss, high-efficiency LC separation, and electrospray. The main body of the Falcon probe is made of stainless steel and fabricated by the computer numerica ...[more]

PMID: 39075986

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