Proteomics

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Proteomic analysis of UCHL1 conditional knockout mice

ABSTRACT: Proteomic analysis of osteoclast precursor cells of UCHL1 conditional knockout mice and wild-type mice was performed

ORGANISM(S): Mus Musculus

SUBMITTER: Tianyu Chen  

PROVIDER: PXD052578 | iProX | Wed Aug 14 00:00:00 BST 2024

REPOSITORIES: iProX

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A RANKL-UCHL1-sCD13 negative feedback loop limits osteoclastogenesis in subchondral bone to prevent osteoarthritis progression.

Liang Wenquan W   Feng Ru R   Li Xiaojia X   Duan Xingwei X   Feng Shourui S   Chen Jun J   Li Yicheng Y   Chen Junqi J   Liu Zezheng Z   Wang Xiaogang X   Ruan Guangfeng G   Tang Su'an S   Ding Changhai C   Huang Bin B   Zou Zhipeng Z   Chen Tianyu T  

Nature communications 20241010 1

Abnormal subchondral bone remodeling plays a pivotal role in the progression of osteoarthritis (OA). Here, we analyzed subchondral bone samples from OA patients and observed a significant upregulation of ubiquitin carboxy-terminal hydrolase L1 (UCHL1) specifically in subchondral bone osteoclasts. Notably, we found a strong correlation between UCHL1 expression and osteoclast activity in the subchondral bone during OA progression in both human and murine models. Conditional UCHL1 deletion in osteo  ...[more]

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