Proteomics

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Hematopoietic stem and progenitor cell membrane-coated vesicles for bone marrow-targeted leukaemia drug delivery

ABSTRACT: To investigate the cellular and molecular mechanisms underlying the specific targeting of HSPC-Lipo nanoparticles to the bone marrow of leukemic mice, we performed mass spectrometry to map the proteomics of HSPC-Lipo nanoparticles and HSPC cell membrane.

ORGANISM(S): Mus Musculus

SUBMITTER: Pengxu Qian  

PROVIDER: PXD052979 | iProX | Thu Jun 06 00:00:00 BST 2024

REPOSITORIES: iProX

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Hematopoietic stem and progenitor cell membrane-coated vesicles for bone marrow-targeted leukaemia drug delivery.

Li Jinxin J   Wu Honghui H   Yu Zebin Z   Wang Qiwei Q   Zeng Xin X   Qian Wenchang W   Lu Siqi S   Jiang Lingli L   Li Jingyi J   Zhu Meng M   Han Yingli Y   Gao Jianqing J   Qian Pengxu P  

Nature communications 20240707 1

Leukemia is a kind of hematological malignancy originating from bone marrow, which provides essential signals for initiation, progression, and recurrence of leukemia. However, how to specifically deliver drugs to the bone marrow remains elusive. Here, we develop biomimetic vesicles by infusing hematopoietic stem and progenitor cell (HSPC) membrane with liposomes (HSPC liposomes), which migrate to the bone marrow of leukemic mice via hyaluronic acid-CD44 axis. Moreover, the biomimetic vesicles ex  ...[more]

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