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Mass spectrometric profiling of intermolecular disulfide bonds between ROMO1 and its targets

ABSTRACT: Mass spectrometric profiling of intermolecular disulfide bonds between ROMO1 and its targets

ORGANISM(S): Homo Sapiens

SUBMITTER: Heping Cheng

PROVIDER: PXD053027 | iProX | Tue Jun 11 00:00:00 BST 2024

REPOSITORIES: iProX

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ROMO1 overexpression protects the mitochondrial cysteinome from oxidations in aging.

Xu Fengli F Huang Haipeng H Peng Kun K Jian Chongshu C Wu Hao H Jing Zhiwen Z Qiu Shan S Chen Ying Y Liu Keke K Fu Ling L Wang Yanru Y Yang Jing J Duan Xiaotao X Wang Chu C Cheng Heping H Wang Xianhua X

Nature communications 20250603 1

Reactive thiols of proteinaceous cysteines are vital to cell biology by serving as sensor, effector and buffer of environmental redox fluctuations. Being the major source, as well as the prime target, of reactive oxygen species (ROS), mitochondria confront great challenges in preserving their thiol pool. Here we show that ROS modulator 1 (ROMO1), a small inner mitochondrial membrane protein, plays a role in protecting the mitochondrial cysteinome. ROMO1 is redox sensitive and reactive and overex ...[more]

PMID: 40461459

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