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Metaproteomics and metabonomics reveal the metabolic dysfunction of gut microbiota in the Tibetan Minipigs with atherosclerosis

ABSTRACT: Atherosclerosis is fundamental in the development of cardiovascular disease. The unhealthy dietary habits, high fat and cholesterol intake could change the composition of gut microbes and metabolites which play a critical role in the development of atherosclerosis. To characterize the functionality of intestinal microbiome in the AS, we performed an analysis of microbiota proteins by a metaproteomics technique in 6 control samples and 6 feces samples. Using data dependent acquisition (DDA), a total of 8467 peptides with taxonomy annotation were identified and which were correspond to 3851 protein groups.

ORGANISM(S): Sus Scrofa

SUBMITTER: Jinlong Wang

PROVIDER: PXD053097 | iProX | Thu Jun 13 00:00:00 GMT+01:00 2024

REPOSITORIES: iProX

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