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Clinical-proteomic classification and precision treatment strategy of chordoma

ABSTRACT: Clinical-proteomic classification and precision treatment strategy of chordoma

ORGANISM(S): Homo Sapiens

SUBMITTER: Dianwen Song

PROVIDER: PXD053631 | iProX | Thu Jul 04 00:00:00 BST 2024

REPOSITORIES: iProX

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Clinical-proteomic classification and precision treatment strategy of chordoma.

Yin Huabin H Hu Jinbo J Gao Jianxuan J Su Tong T Jin Jiali J Jiang Cong C Yin Wenxuan W Xu Xiaowen X Chang Zhengyan Z Sun Wei W Cai Zhengdong Z Zhou Wang W Wang Ping P Lin Jun J Song Dianwen D Meng Tong T

Cell reports. Medicine 20241004 10

Chordoma is a rare and heterogeneous mesenchymal malignancy, with distinct clinical and biological behaviors. Till now, its comprehensive clinical-molecular characteristics and accurate molecular classification remain obscure. In this research, we enroll 102 patients with chordoma and describe their clinical, imageological, and histopathological features. Through tandem mass tag-based proteomic analysis and nonnegative matrix factorization clustering, we classify chordoma into three molecular su ...[more]

PMID: 39368483

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