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Legionella pneumophila effector LegK3 phosphorylates multiple caspases involved in apoptosis signaling

ABSTRACT: Legionella pneumophila effector Legk3 phosphorylates caspase3/7/9 under infection, transfection, or in vitro purification

ORGANISM(S): Homo Sapiens

SUBMITTER: Xiaoyun Liu

PROVIDER: PXD054088 | iProX | Sat Jul 20 00:00:00 BST 2024

REPOSITORIES: iProX

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Phosphorylation of caspases by a bacterial kinase inhibits host programmed cell death.

Ge Jinli J Wang Ying Y Li Xueyu X Lu Qian Q Yu Hangqian H Liu Hongtao H Ma Kelong K Deng Xuming X Luo Zhao-Qing ZQ Liu Xiaoyun X Qiu Jiazhang J

Nature communications 20240930 1

The intracellular bacterial pathogen Legionella pneumophila utilizes the Dot/Icm system to translocate over 330 effectors into the host cytosol. These virulence factors modify a variety of cell processes, including pathways involved in cell death and survival, to promote bacterial proliferation. Here, we show that the effector LegK3 is a eukaryotic-like Ser/Thr kinase that functions to suppress host apoptosis. Mechanistically, LegK3 directly phosphorylates multiple caspases involved in apoptosis ...[more]

PMID: 39349471

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Legionella pneumophila effector LegK3 directly phosphorylates multiple caspases involved in apoptosis signaling, including Caspase-3, Caspase-7, and Caspase-9

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