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Spatial multiomics for liver cancer

ABSTRACT: We selected 24 formalin-fixed paraffin-embedded tissue blocks from 6 patients with primary liver cancer (PLC) and who underwent surgical resection at Eastern Hepatobiliary Surgery Hospital (EHBH) for proteomics analysis,

ORGANISM(S): Homo Sapiens

SUBMITTER: Yufei He

PROVIDER: PXD054095 | iProX | Fri Jul 19 00:00:00 BST 2024

REPOSITORIES: iProX

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Publications

Spatial multiomics reveals a subpopulation of fibroblasts associated with cancer stemness in human hepatocellular carcinoma.

Jing Si-Yu SY Liu Dan D Feng Na N Dong Hui H Wang He-Qi HQ Yan Xi X Chen Xu-Feng XF Qu Min-Cheng MC Lin Ping P Yi Bin B Feng Feiling F Chen Lei L Wang Hong-Yang HY Li Hong H He Yu-Fei YF

Genome medicine 20240813 1

<h4>Background</h4>Cancer-associated fibroblasts (CAFs) are the prominent cell type in the tumor microenvironment (TME), and CAF subsets have been identified in various tumors. However, how CAFs spatially coordinate other cell populations within the liver TME to promote cancer progression remains unclear.<h4>Methods</h4>We combined multi-region proteomics (6 patients, 24 samples), 10X Genomics Visium spatial transcriptomics (11 patients, 25 samples), and multiplexed imaging (92 patients, 264 sam ...[more]

PMID: 39138551

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