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Integrating transcriptomics and proteomics to reveal the role of 125I in hepatocellular carcinoma

ABSTRACT: Our main research focuses on the intervention of iodine-125 radioactive particles on liver cancer cells, inducing changes in gene expression, which may affect changes in biological characteristics. This provides clues for the potential mechanisms of iodine-125 radioactive particle therapy in liver cancer and offers new targets for disease treatment.

ORGANISM(S): Homo Sapiens

SUBMITTER: Yang Yang

PROVIDER: PXD054130 | iProX | Thu Oct 10 00:00:00 BST 2024

REPOSITORIES: iProX

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Integrated transcriptomics and proteomics analysis of the impact of iodine‑125 in hepatocellular carcinoma.

Yang Yang Y Yang Wei W Shen Jie J Ding Enci E

Molecular medicine reports 20250110 3

Hepatocellular carcinoma (HCC) is a common cause of cancer‑related mortality and morbidity worldwide. While iodine‑125 (<sup>125</sup>I) particle brachytherapy has been extensively used in the clinical treatment of various types of cancer, the precise mechanism underlying its effectiveness in treating HCC remains unclear. In the present study, MHCC‑97H cells were treated with <sup>125</sup>I, after which, cell viability and proliferation were assessed using Cell Counting Kit‑8, 5‑ethynyl‑2'‑deox ...[more]

PMID: 39791207

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