Dataset Information

Integrated Landscape of Plasma Metabolism and Proteome for Post-traumatic Deep Vein Thrombosisasma Metabolism and Proteome for Post-traumatic Deep Vein Thrombosis

ABSTRACT: Deep vein thrombosis (DVT) is a leading cause of morbidity and mortality after trauma. Here, we integrate metabolomics and proteomics in up to 680 individuals with and without DVT after trauma (pt-DVT) to reveal the metabolic alterations and their function, and provide potential biomarkers. We carried out a nested case-control study design using a prospective cohort, which enrolled 680 Chinese Han subjects diagnosed with acute traumatic fractures at the Department of Trauma Surgery, Honghui Hospital (Xi’an, China) from October 2018 to October 2022. There were 183 subjects (DVT patients: N=96, Controls: N=87) were used for proteomics analysis.

ORGANISM(S): Homo Sapiens

SUBMITTER: Tielin Yang

PROVIDER: PXD054131 | iProX | Mon Jul 22 00:00:00 BST 2024

REPOSITORIES: iProX

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Publications

Integrated landscape of plasma metabolism and proteome of patients with post-traumatic deep vein thrombosis.

Zhang Kun K Wang Pengfei P Huang Wei W Tang Shi-Hao SH Xue Hanzhong H Wu Hao H Zhang Ying Y Rong Yu Y Dong Shan-Shan SS Chen Jia-Bin JB Zou Yan Y Tian Ding D Yang Na N Liang Yifan Y Liu Chungui C Li Dongyang D Zhang Kun K Yang Tie-Lin TL Guo Yan Y

Nature communications 20240907 1

Deep vein thrombosis (DVT) is a leading cause of morbidity and mortality after trauma. Here, we integrate plasma metabolomics and proteomics to evaluate the metabolic alterations and their function in up to 680 individuals with and without DVT after trauma (pt-DVT). We identify 28 metabolites and 2 clinical parameter clusters associated with pt-DVT. Then, we develop a panel of 9 metabolites (hexadecanedioic acid, pyruvic acid, L-Carnitine, serotonin, PE(P-18:1(11Z)/18:2(9Z,12Z)), 3-Hydroxycapric ...[more]

PMID: 39244606

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Project description:Background: Venothromboembolism (VTE) including deep venous thrombosis (DVT) and pulmonary embolism (PE) are significant health care problems. A highly specific DVT risk stratification model requires a combination of genetic, environmental, clinical, laboratory and radiographic measurements. Genetic factors associated with DVT in post-hospitalized medical and surgical patients are incompletely understood. Aim: Using the Personalized Medicine Research Project (PMRP) population and a limited number of disease associated polymorphisms were used to determine whether these markers were associated with DVT in the post-hospitlalization period. Methods: Marshfield Clinic patients who have experienced a DVT between 1999 and 2007 enrolled in the PMRP were genotyped for 52 disease associated polymorphisms (N=1124). From these individuals we identified 451 who experienced a DVT after post-hospitalization for a medical (N=164) or surgical (N=136) procedure or both (N=151). This cohort was compared to the PMRP population that had a recorded hospitalization without a post-hospitalization DVT during the same time period (N=1662). Results: Polymorphisms in APOB (rs1042031), PLAU (rs2227564), HTR2A (rs6313) and the Vitamin D receptor haplotype (rs731236 and rs7975232) were associated with post hospitalization DVT. When the population that incurred a DVT was stratified by DVT category (post medical, post surgical or both), the PLAU polymorphism was most strongly associated with individuals experiencing a DVT post-surgically. Vitamin D receptor haplotype was significantly associated with individuals experiencing both post medical and post surgical DVTs, and polymorphisms associated with cholesterol and lipid levels were most likely to be associated with post-medical DVTs. Conclusions: This hypothesis generating study demonstrates that there are many polymorphisms that are associated with DVT that have yet to be characterized. Categorization of associated DVT polymorphisms will involve careful interrogation of both the environmental conditions as well as genetic alleles of individuals. Genes such as PLAU, HTR2A, and Vitamin D are just now being investigated for thrombogenic effects and in future may lead to a better understanding of indentifying the individuals at risk for a DVT post hospitilization.

Dataset Information

Integrated Landscape of Plasma Metabolism and Proteome for Post-traumatic Deep Vein Thrombosisasma Metabolism and Proteome for Post-traumatic Deep Vein Thrombosis

Publications

Integrated landscape of plasma metabolism and proteome of patients with post-traumatic deep vein thrombosis.

Similar Datasets

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