P. micra surface protein TmpC interacts directly with OSCC cell lines via CKAP4

ABSTRACT: P. micra surface protein TmpC interacts directly with OSCC cell lines via CKAP4, a receptor frequently overexpressed in human OSCC tumors. The interaction of TmpC and CKAP4 mediates bacterial attachment, invasion, and metastasis-promoting effects of P. micra on OSCC and subsequently activates HIF-1α and autophagy signaling, via CKAP4-RanBP2 and CKAP4-NBR1 interaction, respectively.

ORGANISM(S): Homo Sapiens

SUBMITTER: Qiang Feng  

PROVIDER: PXD054166 | iProX | Wed Jul 24 00:00:00 GMT+01:00 2024

REPOSITORIES: iProX